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Author (up) Itoh, H.; Ito, H.; Hibasami, H. url  openurl
  Title Blazein of a new steroid isolated from Agaricus blazei Murrill (himematsutake) induces cell death and morphological change indicative of apoptotic chromatin condensation in human lung cancer LU99 and stomach cancer KATO III cells Type Journal Article
  Year 2008 Publication Oncology Reports Abbreviated Journal Oncol Rep  
  Volume 20 Issue 6 Pages 1359-1361  
  Keywords  
  Abstract Blazein was isolated from mushroom (Agaricus blazei Murrill) and identified by Mass and 1H-NMR as blazein. The effect of blazein on the DNA of human various cancer cells was investigated. DNA fragmentations by blazein to oligonucreosomal-sized fragments, a characteristic of apoptosis, were observed in the human lung LU99 and stomach KATO III cancer cells. The DNA fragmentations by blazein were observed from day 2 (KATO III cells) or day 3 (LU99 cells) after the addition of blazein to the culture cells. These findings suggest that growth inhibition by blazein results from the induction of apoptosis by the compound.  
  Address Faculty of Bioresources, Mie University, Mie 514-0001, Japan  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1021-335X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:19020714 Approved no  
  Call Number refbase @ user @ Serial 15  
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