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Author  |
Takimoto, H.; Kato, H.; Kaneko, M.; Kumazawa, Y. |
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Title |
Amelioration of skewed Th1/Th2 balance in tumor-bearing and asthma-induced mice by oral administration of Agaricus blazei extracts |
Type |
Journal Article |
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Year |
2008 |
Publication |
Immunopharmacology and Immunotoxicology |
Abbreviated Journal |
Immunopharmacol Immunotoxicol |
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Volume |
30 |
Issue |
4 |
Pages |
747-760 |
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Abstract |
We showed in a previous study that hot-water extracts of Agaricus blazei (Agaricus extracts) had anti-tumor activity to Meth A fibrosarcoma, but it remains unclear whether the Agaricus extracts ameliorate the skewed balance of type-1 T helper (Th1) and type-2 T helper (Th2) cells. We examined whether Agaricus extracts effect the skewed Th1/Th2 balance in tumor-bearing and asthma-induced mice. When Meth A-bearing mice were given orally either Agaricus extracts or water once a day starting 5 days after tumor implantation, spleen T cells, prepared from tumor-bearing mice treated with Agaricus extracts, in response to anti-CD3 monoclonal antibody produced significantly higher levels of interferon gamma (IFN-gamma) than that of controls. The mRNA expression of IFN-gamma-inducing protein 10 and the frequency of CD69(+) or CD49d(+) cells, among activated T cells infiltrated into tumors, significantly increased in Agaricus-treated mice, compared with those of tumor-controls. In asthma-induced mice, treatment with the Agaricus extracts caused significant downregulation of OVA-specific antibody responses of IgG1 and IgE but not of IgG2a, and significantly decreased total cell numbers, levels of interleukin 5, and eosinophil numbers in bronchial alveolar lavage fluids. IFN-gamma production by anti-CD3-stimulated spleen cells, obtained from Agaricus-treated mice, significantly increased. Our results strongly suggest that oral administration of Agaricus extracts ameliorates the Th1/Th2 balance from the Th2-skewed conditions. |
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Address |
Department of Biosciences, School of Science and Graduate School of Science, Kitasato University, Sagamihara, Kanagawa, Japan. takimoto@sci.kitasato-u.ac.jp |
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Language |
English |
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ISSN |
1532-2513 |
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Notes |
PMID:18720167 |
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no |
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Call Number |
refbase @ user @ |
Serial |
26 |
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